Featured Publications

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Loss of mu opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia
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Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back
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Angiotensin receptor blockade mimics the effect of exercise on recovery after orthopaedic trauma by decreasing pain and improving muscle regeneration.

Publications

2021

  • Huck NA, Siliezar-Doyle J*, Haight ES*, Ishida R, Forman TE, Wu S, Shen H, Takemura Y, Clark JD, Tawfik VL. Temporal contribution of myeloid-lineage TLR4 to the transition to chronic pain: A focus on sex differences. Journal of Neuroscience. 2021 Apr 10; DOI: 10.1523/JNEUROSCI.1940-20.2021
  • Johnson EM, Biswal S, Curtin C, Yoon D, Fox P, Wilson TJ, Lutz A, Carroll IR, Tawfik VL. An interdisciplinary approach utilizing magnetic resonance neurography to improve diagnosis in patients with complex refractory limb pain. Frontiers in Pain Research. 2021 May 31; doi.org/10.3389/fpain.2021.689402
  • Grace P, Tawfik VL, Svensson CI, Burton MD, Loggia ML, Hutchinson MR. Journal of Neuroscience. 2021 Feb 3; 41(5): 855-865. doi: 10.1523/JNEUROSCI.1650-20.2020.
  • Shen H, Gardner A, Vyas J, Tawfik VL. Models of complex orthotrauma in rodents: bone, muscle and nerve injury, and healing. Frontiers in Pharmacology. 2021 Feb 1; 11: 620485. doi: 10.3389/fphar.2020.620485

2020

  • Obal D, Wu S, McKinstry-Wu A, Tawfik VL. A guide to Understanding “State-of-the-Art” Basic Research Techniques in Anesthesiology. Anesthesia & Analgesia. 2020. Aug; 131(2): 450-463.
  • Tawfik VL, Quarta M, Paine P, Forman TE, Pajarinen J, Takemura Y, Goodman SB, Rando TA, Clark JD. Angiotensin receptor blockade mimics the effects of exercise on recovery after orthopaedic trauma by decreasing pain and improving muscle regeneration. J Physiology. 2020 Jan; 598(2): 317-329.
  • Tawfik VL, Huck NA, Baca QJ, Ganio E, Haight ES, Culos A, Ghaemi S, Angst MS, Clark JD, Aghaeepour N, Gaudilliere B. Systematic immunophenotyping reveals sex-specific responses after painful injury in mice. Frontiers in Immunology.
  • Haight ES, Johnson EM, Carroll IR, Tawfik VL. Of mice, microglia, and (wo)men: a case series and mechanistic investigation of hydroxychloroquine for complex regional pain syndrome. Pain Reports. 2020 Sept-Oct; 5(5): e841.
  • Haight ES, Huck NA, Jordan CE, Tawfik VL. Complex Regional Pain Syndrome: Pathophysiology, Prognosis and Natural History. In E. Lawson, J. Castellanos (Eds.) Complex Regional Pain Syndrome. Springer, New York, NY.

2019

  • Haight, E. S., Chen, F., Tanaka, P., Brock-Utne, J. G., Macario, A., Sun, E. C., Tawfik, V. L. Predictors of post-anaesthesiology residency research productivity: preliminary report. British journal of anaesthesia.  2019
  • Haight, E. S., Forman, T. E., Cordonnier, S. A., James, M. L., Tawfik, V. L. Microglial Modulation as a Target for Chronic Pain: From the Bench to the Bedside and Back. Anesthesia and analgesia. 2019; 128 (4): 737–46
  • Cropper, H. C., Johnson, E. M., Haight, E., Cordonnier, S. A., Chaney, A. M., Forman, T. E., Biswal, A., Stevens, M. Y., James, M. L., Tawfik, V. L. Longitudinal TSPO-PET imaging of peripheral and central myeloid cells in a mouse model of complex regional pain syndrome. Pain, 2019
  • Kuzumaki, N., Suda, Y., Iwasawa, C., Narita, M., Sone, T., Watanabe, M., Maekawa, A., Matsumoto, T., Akamatsu, W., Igarashi, K., Tamura, H., Takeshima, H., Tawfik, V. L., Ushijima, T., Hattori, N., Okano, H., Narita, M. Cell-specific overexpression of COMT in dopaminergic neurons of Parkinson’s disease. Brain : a journal of neurology. 2019; 142 (6): 1675–89
  • Cipriano, P., Yoon, D., Carroll, I., Curtin, C., Tawfik, V., Xu, Y., Biswal, S. 18F-FDG PET/MRI of patients with chronic pain alters management. SOC NUCLEAR MEDICINE INC. 2019
  • Yoon, D., Xu, Y., Cipriano, P., Tawfik, V., Curtin, C., Carroll, I., Biswal, S. Musculoskeletal changes on [18F]FDG PET/MRI from complex regional pain syndrome in foot. SOC NUCLEAR MEDICINE INC. 2019
  • Li, W., Irvine, K., Sahbaie, P., Guo, T., Shi, X., Tawfik, V. L., Kingery, W. S., Clark, J. Morphine Exacerbates Postfracture Nociceptive Sensitization, Functional Impairment, and Microglial Activation in Mice. ANESTHESIOLOGY  2019; 130 (2): 292–308
  • Schwan, J., Sclafani, J., Tawfik, V. L. Chronic Pain Management in the Elderly. Anesthesiology clinics.  2019; 37 (3): 547–60

2018

  • Li, W., Irvine, K., Sahbaie, P., Guo, T., Shi, X., Tawfik, V. L., Kingery, W. S., Clark, J. D. Morphine Exacerbates Postfracture Nociceptive Sensitization, Functional Impairment, and Microglial Activation in Mice. Anesthesiology. 2018
  • Clark, J. D., Tawfik, V., Tajerian, M., Kingery, W. [EXPRESS] Autoinflammatory and Autoimmune Contributions to Complex Regional Pain Syndrome. Molecular pain. 2018: 1744806918799127
  • Wang, D., Tawfik, V. L., Corder, G., Low, S. A., Francois, A., Basbaum, A. I., Scherrer, G. Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. NEURON  2018; 98 (1): 90-
  • Takemura, Y., Clark, D., Forman, T., Haight, E., Tawfik, V. TEMPORAL CONTROL OF MICROGLIAL REACTIVITY REVEALS SEX-INDEPENDENT FUNCTIONAL CONTRIBUTION OF MICROGLIA TO LONG-LASTING PAIN.  LIPPINCOTT WILLIAMS & WILKINS. 2018: 437
  • Watanabe, M., Narita, M., Hamada, Y., Yamashita, A., Tamura, H., Ikegami, D., Kondo, T., Shinzato, T., Shimizu, T., Fukuchi, Y., Muto, A., Okano, H., Yamanaka, A., Tawfik, V. L., Kuzumaki, N., Navratilova, E., Porreca, F., Narita, M. Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. MOLECULAR PAIN.  2018; 14: 1744806918756406
  • Cipriano, P., Lee, S., Yoon, D., Shen, B., Tawfik, V., Curtin, C., Dragoo, J. L., James, M., Mccurdy, C., Chin, F., Biswal, S. Successful treatment of chronic knee pain following localization by a sigma-1 receptor radioligand and PET/MRI: a case report. JOURNAL OF PAIN RESEARCH. 2018; 11: 2353–56

2017

  • Low, S. A., Robbins, W., Tawfik, V. L. Complex management of a patient with refractory primary erythromelalgia lacking a SCN9A mutation.  JOURNAL OF PAIN RESEARCH.   2017; 10: 973-977
  • Corder, G., Tawfik, V. L., Wang, D., Sypek, E. I., Low, S. A., Dickinson, J. R., Sotoudeh, C., Clark, J. D., Barres, B. A., Bohlen, C. J., Scherrer, G.Loss of mu opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia.  NATURE MEDICINE.  2017; 23 (2): 164-173

2016

  • Adelus, M., Sturgeon, J., RICO, T., Tawfik, V., Mackey, S. (118) Physical and psychological predictors of dysfunction in complex regional pain syndrome (CRPS): a Collaborative Health Outcomes Information Registry (CHOIR) study. journal of pain .2016; 17 (4S): S5-?
  • Adelus, M., Sturgeon, J., RICO, T., Tawfik, V., Mackey, S. (218) Characterization of patients with complex regional pain syndrome (CRPS) in a tertiary care pain management setting: A Collaborative Health Outcomes Information Registry (CHOIR) study. journal of pain.  2016; 17 (4S): S30-?
  • Tawfik, V. L., Flood, P. Electrical Synapses High-speed Communication in the Maintenance of Neuropathic Pain.  ANESTHESIOLOGY. 2016; 124 (1): 13-15

2015

  • Wu, Y., Kim, J., Tawfik, V. L., Lalchandani, R. R., Scherrer, G., Ding, J. B. Input- and Cell-Type-Specific Endocannabinoid-Dependent LTD in the Striatum.  Cell reports  2015; 10 (1): 75-87.
  • Pradhan, A. A., Tawfik, V. L., Tipton, A. F., Scherrer, G. In vivo techniques to investigate the internalization profile of opioid receptors.  Methods in molecular biology (Clifton, N.J.)  2015; 1230: 87-104

2014

  • Bardoni, R., Tawfik, V. L., Wang, D., Francois, A., Solorzano, C., Shuster, S. A., Choudhury, P., Betelli, C., Cassidy, C., Smith, K., de Nooij, J. C., Mennicken, F., O’Donnell, D., Kieffer, B. L., Woodbury, C. J., Basbaum, A. I., MacDermott, A. B., Scherrer, G. Delta Opioid Receptors Presynaptically Regulate Cutaneous Mechanosensory Neuron Input to the Spinal Cord Dorsal Horn.  NEURON  2014; 81 (6): 1312-1327

2013

  • Carroll, I., Hah, J., Mackey, S., Ottestad, E., Kong, J. T., Lahidji, S., Tawfik, V., Younger, J., Curtin, C. Perioperative interventions to reduce chronic postsurgical pain. Journal of reconstructive microsurgery  2013; 29 (4): 213-222
  • Carroll, I., Hah, J., Mackey, S., Ottestad, E., Kong, J. T., Lahidji, S., Tawfik, V., Younger, J., Curtin, C. Perioperative Interventions to Reduce Chronic Postsurgical Pain.  JOURNAL OF RECONSTRUCTIVE MICROSURGERY 2013; 29 (4): 213-222

2010

  • Tawfik, V. L., Chang, S., Hitti, F. L., Roberts, D. W., Leiter, J. C., Jovanovic, S., Lee, K. H.Deep Brain Stimulation Results in Local Glutamate and Adenosine Release: Investigation Into the Role of Astrocytes.  NEUROSURGERY.  2010; 67 (2): 367-375

2008

  • Tawfik, V. L., Regan, M. R., Haenggeli, C., Lacroix-Fralish, M. L., Nutile-McMenemy, N., Perez, N., Rothstein, J. D., DeLeo, J. A. Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. NEUROSCIENCE.  2008; 152 (4): 1086-1092
  • LaCroix-Fralish, M. L., Tawfik, V. L., Nutile-McMenemy, N., DeLeo, J. A.Neuregulin 1 is a pronociceptive cytokine that is regulated by progesterone in the spinal cord: Implications for sex specific pain modulation.  EUROPEAN JOURNAL OF PAIN. 2008; 12 (1): 94-103

2007

  • Boye, S. M., Grant, R. J., Tawfik, V. L. Intracranial self-stimulation of the dorsal raphe sensitizes psychostimulant locomotion. BEHAVIORAL NEUROSCIENCE. 2007; 121 (3): 550-558
  • Tawfik, V. L., Nutile-McMenemy, N., LaCroix-Fralish, M. L., DeLeo, J. A. Efficacy of propentofylline, a glial modulating agent, on existing mechanical allodynia following peripheral nerve injury. BRAIN BEHAVIOR AND IMMUNITY.  2007; 21 (2): 238-246

2006

  • Tawfik, V. L., LaCroix-Fralish, M. L., Bercury, K. K., Nutile-McMenemy, N., Harris, B. T., DeLeo, J. A. Induction of astrocyte differentiation by propentofylline increases glutamate transporter expression in vitro: Heterogeneity of the quiescent phenotype.  GLIA. 2006; 54 (3): 193-203
  • LaCroix-Fralish, M. L., Tawfik, V. L., Tanga, F. Y., Spratt, K. F., DeLeo, J. A. Differential spinal cord gene expression in rodent models of radicular and neuropathic pain.  ANESTHESIOLOGY.  2006; 104 (6): 1283-1292
  • De Leo, J. A., Tawfik, V. L., LaCroix-Fralish, M. L The tetrapartite synapse: Path to CNS sensitization and chronic pain. PAIN. 2006; 122 (1-2): 17-21
  • Lacroix-Fralish, M. L., Tawfik, V. L., Nutile-McMenemy, N., DeLeo, J. A. Progesterone mediates gonadal hormone differences in tactile and thermal hypersensitivity following L5 nerve root ligation in female rats. NEUROSCIENCE.  2006; 138 (2): 601-608
  • LaCroix-Fralish, M. L., Tawfik, V. L., Spratt, K. F., DeLeo, J. A. Sex differences in lumbar spinal cord gene expression following experimental lumbar radiculopathy.  JOURNAL OF MOLECULAR NEUROSCIENCE. 2006; 30 (3): 283-295
  • LaCroix-Fralish, M. L., Tawfik, V. L., Nutile-McMenemy, N., Harris, B. T., DeLeo, J. A. Differential regulation of neuregulin 1 expression by progesterone in astrocytes and neurons. NEURON GLIA BIOLOGY 2006; 2: 227-234

2005

  • M. A., Tawfik, V. L. Safety issues concerning the medical use of cannabis and cannabinoids. Pain research & management. Ware. 2005; 10: 31A-7A
  • Tawfik, V. L., Lacroix-Fralish, M. L., Nutile-McMeneny, N., DeLeo, J. A. Transcriptional and translational regulation of glial activation by morphine in a rodent model of neuropathic pain.  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2005; 313 (3): 1239-1247
  • Lacroix-Fralish, M. L., Tawfik, V. L., DeLeo, J. A. The organizational and activational effects of sex hormones on tactile and thermal hypersensitivity following lumbar nerve root injury in male and female rats.  PAIN.  2005; 114 (1-2): 71-80

2004

  • DeLeo, J. A., Tanga, F. Y., Tawfik, V. L. Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. Neuroscientist. 2004; 10 (1): 40-52

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